In the folic acid metabolism pathway, single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) and methionine synthetase reductase (MTRR) can affect the activity of MTHFR and MTRR synthase, and Affects the level of serum folic acid or homocysteine. It will cause hypofolate and hyperhomocysteinemia, which will increase the risk of birth defects, neural tube diseases and cardiovascular diseases in newborns.
  The "China Cardiovascular Disease 2015" report shows that: China's cardiovascular disease accounts for the highest mortality rate of residents in China, and the number of cardiovascular patients will continue to increase in the next ten years. At the same time, there are about 800-1.2 million new cases of birth defects in China every year. Therefore, folic acid gene testing is carried out to personalize folic acid supplementation for people with folic acid mutations, so as to fundamentally prevent the risks of birth defects, neural tube diseases and cardiovascular diseases.

Figure 1: Methyltetrahydrolysis (MTHFR)gene C677T(rs1801133) 
Figure 2: Methyl tetrahydrofolilic acid reductase (MTHFR)MTHFRgene A1298C(rs1801131) 
Figure 3: Methylthion synthetic reductase (MTRR)MTRRgene A66G(rs1801394)

Early detection is caused by genetic factors, which can provide guidance for people who lack folic acid to achieve precise medication;
Provide the basis for the onset of hyperhomocysteinemia patients;
Defining the family genetic history and providing guidance for eugenics and personalized medicine;
Gene mutations can be accurately detected.

Comprehensive:The first to detect three major mutations in the Chinese population at the same time, enabling a more comprehensive assessment of the subject's folic acid utilization capacity；
Accurate:Use a large number of clinical samples to verify, and the coincidence rate with sequencing is 100%, to avoid wrong or missed tests;
The operation is simple and fast: one tube detects three sites, which takes less time from the experiment to the results, stable performance, high repeatability, and the test results can be quickly and accurately interpreted, simple and clear；
Genetic testing: Qualitative identification of folic acid risk genes to achieve personalized folic acid supplementation with reliable results for life;

High sensitivity: The detection limit of the genomic DNA of the examinee is 2ng / μL；

National 973 project, top international and domestic experts devote themselves to creating

Analysis of the causes of high-like cysteineemia 
Pregnant women: prevention of birth defects, spontaneous abortion, pregnancy hypertension, etc. 
Women with a bad pregnancy history: prevention of adverse pregnancy recurrence

Detection of specimens: Anticoagulant whole blood or genomic DNA

Technical principle: PCR-fluorescent melting method

Packing size:24 tests / kit,48 tests / kit

Category:In vitro diagnostic reagents

Suitable for instruments: Fluorescence quantitative PCR instrument